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Published research is separate from the batch test results for this vial.
Browse the research libraryNonapeptide isolated from mammalian brain. Investigated for delta-wave sleep induction and stress-response modulation in animal models.
Listed Purity
99.50%
Method
HPLC
Certificate
Not published$13.00 / mg
In stock, ships from Sydney
For research use only. Not for human consumption. By purchasing this product, you confirm it will be used solely for legitimate research purposes.
Nonapeptide isolated from mammalian brain. Investigated for delta-wave sleep induction and stress-response modulation in animal models.
DSIP (Delta Sleep-Inducing Peptide) is a nine-amino-acid endogenous neuropeptide first isolated in 1977 by Monnier, Schoenenberger and colleagues from the cerebral venous blood of rabbits in electrically induced slow-wave sleep. It has been investigated in published animal research for its role in delta-wave sleep architecture and stress-response pathways.
This vial contains 5mg of DSIP as a lyophilised powder for reconstitution with sterile diluent in the laboratory.
DSIP is a small endogenous peptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. It was named for the observation that its infusion into rabbits in behavioural experiments appeared to increase the proportion of delta-wave activity on electroencephalography recordings during sleep.
Published animal research has investigated DSIP in the context of:
The precise molecular mechanism of DSIP is still poorly characterised in the published literature. It does not appear to bind a single well-defined receptor in the way many neuropeptides do, and its central nervous system effects in animal models have been studied across multiple signalling pathways, including those involving the hypothalamic-pituitary axis.
Early pharmacokinetic work describes a short serum half-life and rapid tissue distribution, which is a central consideration in protocol design for any follow-up research.
Selected areas of published preclinical research include:
Human clinical data is limited and largely historical. DSIP is not approved by the TGA or FDA for any therapeutic indication.
A laboratory report is not currently published for this listing. Contact support about documentation for the size and batch you need before ordering. The vial is shipped lyophilised to preserve stability during transit and should be stored at -20°C prior to reconstitution and 2-8°C after reconstitution in the laboratory.
For background on handling lyophilised research peptides, see our reconstitution calculator.
For research use only. Not for human consumption. The information provided is for educational and research purposes only. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult published peer-reviewed literature before designing research protocols.
