A growth hormone-releasing hormone analogue. Studied for GH secretion and lipid metabolism.
Overview
Tesamorelin is a synthetic analogue of Growth Hormone Releasing Hormone with modifications that improve its stability against enzymatic degradation. It has been investigated in published research for its role in GHRH receptor pharmacology, GH axis research, and lipid metabolism pathways in preclinical and clinical research studies.
This vial contains 10mg of Tesamorelin as a lyophilised powder for reconstitution with sterile diluent in the laboratory.
What is Tesamorelin?
Tesamorelin is a 44-amino-acid peptide that corresponds to the native sequence of human GHRH (1-44) with a trans-3-hexenoic acid modification at the N-terminus. This modification stabilises the peptide against cleavage by dipeptidyl peptidase-4 (DPP-4), extending its half-life in circulation relative to native GHRH.
Published research has investigated Tesamorelin in the context of:
GHRH receptor pharmacology studies
Pulsatile GH secretion research
IGF-1 axis research in animal models
Adipose tissue research in preclinical models
Lipid metabolism pathway studies
Mechanism of Action
Tesamorelin binds to the GHRH receptor on pituitary somatotroph cells, stimulating the release of endogenous growth hormone through the same pathway as native GHRH but with improved stability and duration of action. Published research has explored how sustained activation of this receptor influences downstream markers including IGF-1 and lipid metabolism pathways in preclinical models.
Published Research
Tesamorelin has been the subject of published Phase 3 clinical trial research. Preclinical studies have explored GHRH receptor pharmacology, GH pulse frequency modulation, and IGF-1 response in animal models.
Published research has explored Tesamorelin in the context of:
GHRH receptor binding and signalling research
GH axis research in animal models
IGF-1 pathway research
Visceral adipose tissue research models
Lipid metabolism pathway studies
Tesamorelin is supplied strictly as a research reagent for laboratory research purposes.
Quality and Verification
Every batch ships with a batch-specific Certificate of Analysis documenting purity by HPLC (≥99%) and mass spectrometry confirmation of peptide identity. The vial is shipped lyophilised to preserve stability during transit and should be stored at -20°C prior to reconstitution and 2-8°C after reconstitution in the laboratory.
Further Reading
For background on handling lyophilised research peptides, see our
reconstitution calculator.
Disclaimer
For research use only. Not for human consumption. The information provided is for educational and research purposes only. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult published peer-reviewed literature before designing research protocols.
